Diabetes

Age Range 14-16

Page 4 of 8

  • Diabetes
  • Type 1 and Type 2 diabetes
  • The discovery of insulin
  • Controlling blood glucose levels
  • Treating diabetes
  • Making human insulin
  • Gene therapy for diabetes
  • Quiz

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Controlling blood glucose levels

Detecting diabetes

The simplest way to detect diabetes is to look for glucose in the urine. A glucose test stick changes colour to indicate the level of glucose.

Diabetics regularly monitor their blood glucose level by using a digital monitor. A drop of blood is placed on a test strip and the monitor displays the blood glucose concentration.

A glucose test stick

Simple test sticks can indicate the presence of glucose in the urine.

A digital monitor

Self-monitoring of blood glucose levels is an important aspect of living with diabetes.

Images courtesy of: Wellcome Images

Glucose tolerance test

To confirm diabetes, a person will normally take a glucose tolerance test in a hospital.

Patients do not eat for 12 hours before the test. This gets their blood glucose to its lowest level. They are then given a drink containing 75g of glucose and their blood glucose level is monitored over the next two hours.

Diabetics will rapidly become hyperglycaemic. Their blood glucose level rises and remains above normal.

Healthy individuals will release insulin to store the excess glucose. Their blood glucose level rises but then returns to normal.

Blood glucose in the diabetic rises and stays above normal

Blood glucose in the diabetic rises and stays above normal.
The healthy person regulates their glucose back to normal.

Control of blood glucose levels

Every cell in the body needs a supply of glucose to maintain respiration and generate energy for all of its processes. Levels of glucose (sugar) in the blood are closely controlled by two hormones ; insulin and glucagon .

Use the animation to see how the body responds to high and low blood sugar levels:

Question 2

Drag the responses into the correct columns

Blood sugar too high Blood sugar too low
   
insulin produced
glucagon produced
liver releases glucose
liver stores glycogen
 
Autoimmune disease
A disorder where the body's immune system behaves abnormally and starts attacking its own cells
Autopsies
The study of the human body to investigate how a disease or injury lead to death
Cardiovascular disorders
Diseases linked to the heart and its blood vessels, for example heart disease and stroke
Embryo
The name for a group of cells that are developing into a fetus. In humans this is from implantation to the 8th week of development
Glossary
A list of often difficult or specialized words with their definitions
Fermentation
Process where microorganisms are cultured so that they reproduce and increase in quantity
Gene
A short piece of DNA which is responsible for the inheritance of a particular characteristic. It codes for the production of a specific protein
Gene therapy
A new, experimental method of fighting disease by replacing a defective gene with a healthy gene
Genetic engineering
A general name for the processes which scientists use to produce desired characteristics or substances that are in short supply, such as human insulin
Glucagon
A hormone produced by the pancreas. It causes the liver to convert glycogen back to glucose and to release glucose into the bloodstream.
Glucose
A type of sugar: a mono saccharide with 6 carbon atoms (a hexose sugar)
Harvested
The process by which a useful substance is extracted
Home Office
The UK government department responsible for regulating the use of animals in scientific research
Hormone
A chemical messenger produced by a particular gland or cells of the endocrine system. Hormones are transported throughout the body in the blood stream but they produce a response only in specific target cells
Hyperglycaemic
This is the term used when the blood glucose level is too high (more than 10 mmol/l)
Hypoglycaemic
This is the term used when the blood glucose level is too low (less than 4 mmol/l)
Immune system
The body's own system for protecting it against disease (where it produces antibodies to attack invading pathogens)
In vitro fertilisation
A process where the egg is fertilised outside of the body and then transferred back into the uterus to develop normally
Insulin
A hormone produced by the pancreas. It allows cells in the body to take in and store glucose.
Liver
A large organ in the upper abdomen which manufactures, stores and breaks down substances as required by the body
Non-animal alternatives
Processes such as cell culture, computer modelling, imaging and microdosing of human volunteers that can give information on potential harmful effects of a substance
Obesity
A disorder where an excessive amount of fat has accumulated in the body. It results when the energy taken in as food is stored in the body instead of being used up through activity
Pancreas
An endocrine gland which produces insulin
Respiration
The biochemical process by which the cells in the body releases energy
Sterile
Uncontaminated by microorganisms
UK Law [for animal testing]
Animal welfare is regulated in the UK by the Animal (Scientific Procedures) Act 1986